De novo chemoenzymatic synthesis of sialic acid.
نویسندگان
چکیده
A chemoenzymatic synthesis of sialic acid from inexpensive N-acetyl-D-glucosamine is described. In a three-step Wittig-protection-ozonolysis strategy manno-configured aldehydes are obtained. Treatment with oxaloacetate in the presence of macrophomate synthase affords the signature α-keto-γ-hydroxy acid moiety with high diastereoselectivity.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 98 شماره
صفحات -
تاریخ انتشار 2012